If You Take Omeprazole or Esomeprazole, You Could Be Losing B12, Magnesium, Calcium & Iron Daily.

Introducing Reflux Replenish by Gutvitals – The Only Supplement Specially Developed to Replenish Key Nutrients Depleted by PPI Use.

  • The First and Only Supplement Made for PPI Users
  • Replenishes Essential Nutrients Lost Due to PPIs
  • High-Bioavailability & Stomach-Friendly Formula
  • Doctor-Formulated for Optimal Absorption
  • Includes Probiotics for Gut Health

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But why do these medications deplete your body’s nutrients in the first place?

The Hidden Chain Reaction Behind Nutrient Deficiency in PPI Users

You Take a PPI (e.g., Omeprazole)

To relieve heartburn or reflux symptoms

Stomach Acid Production Drops

Less acid means weaker digestion

Nutrient Absorption Gets Impaired

Body can’t absorb enough essential vitamins

You Develop Deficiencies Over Time

Leading to brain fog, fatigue, bone loss and other symptoms

What Are PPIs and Why Do They Deplete Your Body’s Nutrients?

Proton Pump Inhibitors (PPIs) are very commonly used to treat acidreflux and related issues — but they may silently strip your body of vital nutrients, especially after prolonged use.

PPIs are commonly used to reduce stomach acid and treat:

  • GERD (Acid Reflux)
  • Peptic Ulcers
  • Chronic Heartburn
  • Esophagitis & Barrett’s Esophagus

Examples of commonly prescribed PPIs in the United States include:

  1. Omeprazole (Prilosec®)
  2. Esomeprazole (Nexium®)
  3. Lansoprazole (Prevacid®)
  4. Dexlansoprazole (Dexilant®)
  5. Pantoprazole (Protonix®)
  6. Rabeprazole (AcipHex®)

All product names are the property of their respective owners.

So what happens when your body runs low on these essential nutrients? You may already be feeling it…

Feeling Off Lately? Your PPI Might Be Depleting Vital Nutrients

Here Are Common Symptoms Linked to Nutrient Deficiencies Caused by Long-Term PPI Use:
Did You Know? Research shows that up to 50% of long-term PPI users suffer from at least one nutrient deficiency.

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This is exactly why we created Reflux Replenish — to help replenish what your PPI may be taking away.

The Complete Nutrient and Gut Support Formula for PPI Users

Reflux Replenish by GutVitals is expertly designed to restore the nutrients most depleted by PPIs — while supporting your gut with probiotics.

Doctor-Formulated for Maximum Absorption

High-Bioavailability Nutrients

Probiotic-Infused for Gut Health

Vegan, Non-GMO & Gentle on the Stomach

Support Your Health Before Deficiencies Set In — Join the Launch List

This is exactly why we created Reflux Replenish — to help replenish what your PPI may be taking away.

The Science Behind Reflux Replenish

Clinically Supported. Evidence-Backed. Nutrient Replenishment for PPI Users Isn't Just Helpful — It's Essential.

The Risks and Benefits of Long-term Use of Proton Pump Inhibitors

Long-term PPI use is linked to several nutrient deficiencies, prompting expert advice to monitor patients for risks like vitamin and mineral depletion.

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Associations of Atrophic Gastritis and Proton-Pump Inhibitor Drug

PPI use is significantly associated with lower vitamin B12 levels and impaired biomarkers, confirming long-term nutrient depletion risk in U.S. adults.

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Effect of Proton Pump Inhibitors on Vitamins and Iron

PPIs reduce absorption of vitamin C, vitamin B12 and iron - potentially causing deficiencies by interfering with release and uptake mechanisms in the stomach.

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PPIs and Hypomagnesemia in the General Population

Long-term PPI use is linked to hypomagnesemia, indicating that continuous acid suppression can lead to significant magnesium depletion, affecting overall health.

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Do Proton Pump Inhibitors Decrease Calcium Absorption?

Study links PPI use to increased fracture risk, highlighting reduced calcium absorption and nutrient disruption— especially in postmenopausal women using PPIs long-term.

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Use of Proton Pump Inhibitors and Risk of Iron Deficiency

Long-term PPI users had significantly higher odds of iron deficiency, confirming that continuous acid suppression impairs nutrient absorption and depletes essential minerals like iron.

Read Full Study

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